Described by comedy peer Lewis Black as the "funniest woman in America", the winner of the American Comedy Award for Best Female Comedian is a triple threat; as well as her sell-out tours, Madigan is a favorite on late-night talk shows and nationally syndicated radio shows. With an enviable career spanning three decades on the comedy circuit, she has the distinction of being one of few comics to appear on every major late-night show including Leno, Letterman, Conan, and Ferguson.

Whose Live Anyway (originally called A Night of Improv) first appeared in 1999 when it sold out two shows in under three hours to very enthusiastic crowds in Vancouver. Following its initial success, Whose Line Executive Producer and star Ryan Stiles expanded the number of appearances of the show to include many major cities in the Western USA and Canada where it has remained a constant sell-out.